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Mikel Arteta makes five changes to their starting XI from the side which faced Southampton on Thursday evening.
Coming in are Maitland-Niles, David Luiz, Willock, Kolasinac and Lacazette, in place of Bellerin, Holding, Ceballos, Aubameyang and Nketiah, who are all amongst the substitutes
Sheffield United: Henderson, Baldock, Stevens, Fleck, Basham, Lundstram, McBurnie, Egan, Norwood, McGoldrick, Robinson.
Sheffield United substitutes: L. Freeman, Sharp, Jagielka, K. Freeman, Mousset, Osborn, Moore, Zivkovic, Berge
Arsenal: Martinez, Mustafi, David Luiz, Tierney, Maitland-Niles, Xhaka, Willock, Kolasinac, Pepe, Lacazette, Saka
Arsenal substitutes: Macey, Bellerin, Sokratis, Holding, Smith, Caballos, Nelson, Nketiah, Aubameyang
Referee: Paul Tierney
Assistants: Ian Hussin and Marc Perry
Fourth Official: Robert Jones